WT1 and kidney progenitor cells
نویسندگان
چکیده
منابع مشابه
Endothelial progenitor cells in chronic kidney disease.
10. Pierce RA, Mariencheck WI, Sandefur S et al. Glucocorticoids upregulate tropoelastin expression during late stages of fetal lung development. Am J Physiol 1995; 268: L491–L500 11. McGowan SE, Doro MM, Jackson SK. Endogenous retinoids increase perinatal elastin gene expression in rat lung fibroblasts and fetal explants. Am J Physiol 1997; 273: L410–L416 12. Rose C, Wessel A, Pankau R et al. ...
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The WT1 gene is a tumor-suppressor gene that was isolated as a gene responsible for Wilms' tumor, a childhood kidney neoplasm. We have previously reported that the WT1 gene is strongly expressed in leukemia cells with an increase in its expression levels at relapse and an inverse correlation between its expression levels and prognosis, thus making it a novel tumor marker for leukemic blast cell...
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Hematologic malignancies such as acute and chronic myeloid leukemia are characterized by the malignant transformation of immature CD34(+) progenitor cells. Transformation is associated with elevated expression of the Wilm's tumor gene encoded transcription factor (WT1). Here we demonstrate that WT1 can serve as a target for cytotoxic T lymphocytes (CTL) with exquisite specificity for leukemic p...
متن کاملThe Wilms' tumor suppressor Wt1 activates transcription of the erythropoietin receptor in hematopoietic progenitor cells.
The Wilms' tumor protein Wt1 is required for embryonic development and has been implicated in hematologic disorders. Since Wt1 deficiency may compromise the proliferation and differentiation of erythroid progenitor cells, we analyzed the possible role of the transcriptionally active Wt1 isoform, Wt1(-KTS), in regulating the expression of the erythropoietin receptor (EpoR). Wt1 and EpoR were coe...
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ژورنال
عنوان ژورنال: Organogenesis
سال: 2010
ISSN: 1547-6278,1555-8592
DOI: 10.4161/org.6.2.11928